NIH Reporter #1ZIAAG000437-04

Research Project: Brain Structure and Cognitive Function in Aging (NIA)

This opportunity involves a research project funded by the National Institute on Aging (NIA), focusing on brain structure and cognitive function in aging. - Government Buyer: - National Institutes of Health (NIH), National Institute on Aging (NIA) - Project Scope: - Research titled 'Linking brain micro- and meso-structure with cognitive functioning' - Development and application of advanced, multidimensional MRI imaging protocols - Integration of pre-clinical and clinical MRI sequences, histological methods, cognitive assessments, and blood biomarker analysis - Investigation of cellular processes underlying brain function, microstructure, and chemical composition in normative aging, mild cognitive impairment, and dementia - Unique Requirements: - Protocol development and testing on clinical MRI scanners - Comprehensive imaging to identify early markers distinguishing healthy aging from pathological conditions such as Alzheimer's disease and other dementias - OEMs and Vendors: - No specific OEMs or vendors are named in the solicitation - Products/Services Requested: - No specific products, part numbers, or purchase quantities are listed

Description

This project combines pre-clinical and clinical MRI sequences with histological methods, cognitive assessment, and blood biomarkers to investigate cellular processes related to brain function, microstructure, and chemical composition in normative aging, mild cognitive impairment, and dementia. The work involves developing and testing a novel multidimensional MRI imaging protocol on a clinical scanner, assessing its reproducibility and reliability. It also includes comprehensive imaging of brain aging microstructure and associating these changes with neurocognitive aging using large cohorts. The findings aim to provide early markers for differentiating healthy aging from pathological conditions such as Alzheimer's and other dementias.

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