NIH Reporter #5R01GM149080-04

NIH Grant Award for Droplet Chemistry and LC-MS Analytical Platform Development

This opportunity involves a grant award from the National Institute of General Medical Sciences (NIGMS), part of the National Institutes of Health, to Ohio State University for advanced analytical platform development. - Government Buyer: - National Institutes of Health (NIH) - National Institute of General Medical Sciences (NIGMS) - Awardee: Ohio State University - Products/Services Requested: - Development of a mass spectrometry platform for high-throughput quantitative analysis - LC-MS (liquid chromatography-mass spectrometry) coupling equipment - Droplet chemistry reagents for accelerated reactions - No specific OEMs or vendors are named for the equipment or reagents - Unique/Notable Requirements: - Creation of a contained-electrospray platform for saccharide analysis - Development of a plasma-droplet fusing source for lipid analysis - Focus on improving disease diagnosis and rare sugar analysis in biomedical research - Estimated award amount: $305,810 - The project aims to enhance biomedical research capabilities through innovative analytical technology

Description

This NIH grant opportunity seeks to develop a platform that couples online accelerated droplet chemistry with liquid chromatography-mass spectrometry (LC-MS) for high-throughput quantitative analysis of complex mixtures, including saccharides and lipids. The project aims to improve characterization of lipids and saccharides for clinical and biomedical research by addressing challenges in mass spectrometry through innovative droplet-based reactions. The research will create versatile platforms for disease diagnosis and analysis of rare sugars, enhancing biomedical research capabilities. The project is led by Ohio State University under the National Institute of General Medical Sciences (NIGMS).

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