NIH Reporter #5R01DK129473-05

NIH Grant Award for Research on Apical Junctional Complex in Bladder Cells

This opportunity is a grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health, for research on bladder cell biology. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) - Recipient Organization: - University of Pittsburgh at Pittsburgh - Project Focus: - Research on the role of the apical junctional complex (AJC) in umbrella cell function and dysfunction in the bladder - Study aims to understand how AJC dynamics maintain bladder function and respond to mechanical stress - Utilizes advanced imaging, mechanotransduction pathway analysis, and functional assays - Products/Services Requested: - No specific products, part numbers, or quantities are listed - No OEMs or vendors are named in the notice - Notable Requirements: - Emphasis on the importance of AJC in bladder health and disease, especially under pathological bladder pressure - Estimated Contract Value: - $636,114

Description

This NIH grant opportunity focuses on studying the apical junctional complex (AJC) in urothelial cells of the bladder. The research aims to understand how the AJC maintains bladder function and responds to mechanical stress such as bladder filling and voiding. The project involves advanced imaging, mechanotransduction pathway analysis, and functional assays to elucidate the role of AJC dynamics in bladder health and disease. It also investigates how pathological bladder pressure affects urothelial cell behavior and contributes to bladder dysfunction.

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