NIH Reporter #5R21AI188438-02

NIH Grant Award for Research on ACPAs in Rheumatoid Arthritis

This opportunity involves a grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, to Johns Hopkins University for biomedical research. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Allergy and Infectious Diseases (NIAID) - Awardee: - Johns Hopkins University, Baltimore, MD - Products/Services Requested: - Scientific research project titled 'Insights into the origin of ACPAs in RA' - Focus on investigating the origin and mechanistic relationship of antibodies to citrullinated and carbamylated proteins in rheumatoid arthritis (RA) - Utilization of RA-derived monoclonal ACPAs for hypothesis testing - OEMs and Vendors: - No specific OEMs or commercial vendors mentioned; this is a research grant - Unique/Notable Requirements: - Submission of materials in PDF or Word format - Virtual pre-bid meeting required - Award amount is $232,875, covering direct and indirect costs - No products or services with part numbers or quantities are requested; the grant is for scientific research activities

Description

This NIH grant opportunity seeks to investigate the origin and mechanistic relationship of antibodies to citrullinated and carbamylated proteins in rheumatoid arthritis (RA). The project aims to explore a novel hypothesis that anti-citrullinated protein antibodies (ACPAs) may arise from antibodies targeting carbamylated proteins. The research will use RA-derived monoclonal ACPAs to test this hypothesis, potentially uncovering mechanisms behind RA development. The work is funded by the National Institute of Allergy and Infectious Diseases and conducted at Johns Hopkins University.

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