SAM #75N98026Q00775

NIH Liver Diseases Branch Automated Cell Counter Procurement

The NIH Liver Diseases Branch is seeking an automated cell counting system to enhance clinical research on immune cells from liver disease patients. - Government Buyer: - National Institutes of Health (NIH), Liver Diseases Branch - Products/Services Requested: - Automated cell counter with image-based analysis - Dual-channel fluorescence and brightfield imaging - Must process at least eight samples per slide - Cell counting must be completed in under 60 seconds - Supports a wide range of sample types: mouse immune cells, bone marrow cells, human blood lymphocytes, hepatocytes, and other primary cell populations - Customizable and storable experimental protocols - Capable of analyzing sample volumes as small as 10 microliters - 21 CFR Part 11 compliance (audit trail, user access control, electronic signature) - Compact footprint (approx. 15 inches deep by 10 inches wide) - Minimum 12-month manufacturer's warranty - OEMs and Vendors: - No specific OEMs or vendors are named in the solicitation - Unique/Notable Requirements: - Emphasis on regulatory compliance (21 CFR Part 11) - Flexibility for various cell types and small sample volumes - Customizable workflow and protocol storage - Compact design for limited bench space

Description

Requirements:

The Liver Diseases Branch requires an automated cell counter to support ongoing clinical research studies involving immune cells obtained from patients with liver disease. These studies require the isolation and quantification of white blood cells for downstream research analyses. 

Currently, white blood cells are counted manually using microscopy. To improve efficiency, increase counting throughput, enhance differentiation between white blood cells and red blood cells, distinguish live and dead cells, and reduce inter-operator variability, the laboratory requires an image-based automated cell counting system with dual-channel fluorescence and brightfield imaging capabilities. 

The following product features and characteristics are required: 

The system shall provide compatibility with existing laboratory workflows and support the use of customizable and saved experimental protocols for ongoing research studies. 

The system shall be capable of processing a minimum of eight samples on a single slide. 

The system shall complete cell counting in less than 60 seconds and provide the ability to capture two, four, or eight images per sample. 

The system shall incorporate dual-channel fluorescence and brightfield imaging capabilities for cell counting and viability assessments.  

 The system shall support analysis of a wide range of sample types, including mouse immune cells, bone marrow cells, human blood lymphocytes, hepatocytes, and other primary cell populations. 

The system shall be capable of analyzing sample volumes as small as 10 microliters. 

The system shall allow users to customize, store, and retrieve commonly used experimental settings and analysis protocols. 

The system shall be capable of supporting 21 CFR Part 11 compliance through available audit trail, user access control, and electronic signature functionality. 

The system shall have a compact footprint suitable for placement on laboratory bench space approximately 15 inches deep and 10 inches wide.  The system shall include a minimum 12-month manufacturer's warranty. 

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