SAM #75N98026Q00764

GLP Histopathology and AAV9 Antibody Screening Services for HGPS Mouse Model Preclinical Trial

The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, is seeking specialized laboratory services for a preclinical trial involving a gene editing therapeutic for Hutchinson Gilford Progeria Syndrome (HGPS) in a humanized mouse model. - Government Buyer: - National Institutes of Health (NIH) - National Human Genome Research Institute (NHGRI) - Services Requested: - GLP-compliant histopathology slide preparation and staining for 60 mice - Up to 18 fixed tissue samples per mouse - Multiple stains: hematoxylin and eosin, Movat's pentachrome, picrosirius red, alizarin red, and unstained slides for immunofluorescence - Organs analyzed include aorta, heart, liver, kidney, brain, lung, spleen, skin, reproductive organs, lymph nodes, adipose tissue, and intestines - AAV9 antibody screening of 60 mouse serum samples - Proprietary FDA-qualified assay for AAV9 antibodies - GLP-compliant documentation required - Deliverables: - GLP-compliant reports - Return of all slides and tissues to NHGRI - Notable Requirements: - All work must be GLP-compliant - Services support a preclinical trial of the SamPro-2 AAV9 gene editing therapeutic - No specific OEMs or commercial laboratory vendors are named in the solicitation

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