Federal Register #2026-13802

License Opportunity for Casq2 Genetically Modified Mouse Strains and HPV Liquid Biopsy Diagnostic Method

This opportunity from the National Institutes of Health (NIH), specifically the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) and the National Cancer Institute (NCI), offers licensing for advanced research tools and diagnostic methods: - Government Buyer: - NIH, NICHD, and NCI - OEMs and Vendors: - The Jackson Laboratory (JAX) is the primary source for genetically modified mouse strains - Products/Services Requested: - Casq2Flox and Casq2RevFlox genetically modified mouse strains (JAX Strain 036291 and 036290) - Conditional and reverse conditional loss-of-function alleles in mouse Casq2 - Used to model catecholaminergic polymorphic ventricular tachycardia (CPVT) - Part number: E1282024 (for both strains) - No specific quantity listed; strains are available for licensing - Liquid biopsy diagnostic method for HPV 6 and 11 DNA - Hybridization-based next-generation sequencing for detecting circulating cell-free HPV DNA - Intended for non-invasive diagnosis and monitoring of recurrent respiratory papillomatosis (RRP) - Unique/Notable Requirements: - Mouse strains are validated, fully functional, and offered as research tools without patent protection - The technology enables tissue- and stage-specific gene function studies and evaluation of gene therapy efficacy - The liquid biopsy method is a novel, non-invasive diagnostic tool for RRP - The opportunity is for licensing these technologies for further development or utilization by interested parties.

Description

The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) is offering a license opportunity for genetically modified Casq2 mouse strains that model catecholaminergic polymorphic ventricular tachycardia (CPVT). These mouse strains allow researchers to study Casq2 gene function in specific tissues and developmental stages, and to evaluate gene therapy efficacy. The technology is offered as a research tool without patent protection. Interested parties can access detailed strain information via provided JAX links.

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