NIH Reporter #5R01NS128080-04

NIH Research Grant for Migraine Chronification and Reversal Mechanisms

This opportunity is a research grant from the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, focused on migraine chronification and reversal mechanisms. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Neurological Disorders and Stroke (NINDS) - Eligible Applicant: - Washington University in Saint Louis, MO - Scope of Work: - Academic research on neuro-immune interactions in chronic migraine - Focus on T cell subsets, neuropeptides (CGRP, PACAP), and ld-IL2 treatment effects - Investigation of signaling pathways and mechanism-based drug discovery - Products/Services Requested: - Research services (no specific commercial products or OEMs required) - Notable Requirements: - Emphasis on mechanism-based approaches for migraine treatment - Study of Treg cells and neuro-immune signaling - Funding Amount: - $462,244 (grant value) - No OEMs or commercial vendors are specified, as this is a research grant for academic investigation.

Description

This NIH research grant opportunity aims to investigate the role of neuro-immune interactions, specifically involving T cells and neuropeptides like CGRP and PACAP, in the development and resolution of chronic migraine. The study will explore how T cell subsets contribute to migraine chronification, the effects of ld-IL2 treatment on Treg cells, and the signaling pathways involved. The goal is to facilitate mechanism-based drug discovery for migraine treatment. The project duration is from April 1, 2023, to March 31, 2028, with an application due date of April 8, 2026.

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