NIH Reporter #5R01NS128094-04

NIH Grant for Research on Astrocyte Reactivity in White Matter Degeneration

This opportunity is a research grant offered by Cedars-Sinai Medical Center in collaboration with the National Institute of Neurological Disorders and Stroke (NINDS): - Government Buyer: - Cedars-Sinai Medical Center (applicant) - National Institute of Neurological Disorders and Stroke (NINDS), part of NIH - Purpose: - Research project focused on dissecting molecular pathways of astrocyte-microglia interaction in white matter degeneration - Aims to understand innate immune responses and develop potential therapeutics - Techniques and Methods: - Utilizes advanced molecular techniques such as single-nucleus RNA sequencing (snRNA-Seq) and single-nucleus ATAC sequencing (snATAC-Seq) - Products/Services Requested: - No specific OEMs, vendors, or commercial products are named - The primary service is scientific research using advanced sequencing technologies - Notable Requirements: - Research must focus on astrocyte reactivity states in white matter degeneration - Emphasis on molecular pathway analysis and therapeutic development - Estimated Value: - Grant valued at $688,606 - Classification: - Falls under Public Health, Related Programs (CFDA Code 93.853)

Description

This NIH grant opportunity aims to dissect molecular pathways of astrocyte-microglia interaction in white matter degeneration. The research involves advanced techniques such as snRNA-Seq and snATAC-Seq to understand innate immune responses. The goal is to develop potential therapeutics targeting these pathways. The project is conducted by Cedars-Sinai Medical Center under the National Institute of Neurological Disorders and Stroke (NINDS).

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