NIH Reporter #11241528

Award for research on DNA replication forks and formaldehyde mutagenesis by National Cancer Institute

This award notice announces funding by the National Cancer Institute (NCI) for research on DNA replication forks and formaldehyde mutagenesis. - Government Buyer: - National Cancer Institute (NCI), part of the US Department of Health and Human Services - Awardee: - Medical University of South Carolina, Department of Biochemistry - Products/Services Requested: - Research services focused on dysregulated DNA replication forks as targets for formaldehyde mutagenesis - No specific products, part numbers, or purchase quantities are listed - Unique or Notable Requirements: - Research aims to identify how single-stranded DNA at replication forks is affected by formaldehyde, a class I carcinogen - Focus on individuals with DNA repair and replication disorders who may be at higher risk for formaldehyde-induced carcinogenesis - OEMs and Vendors: - No OEMs or commercial vendors are mentioned in the award - Estimated Contract Value: - $47,639

Description

This project investigates the role of dysregulated DNA replication forks as targets for formaldehyde-induced mutagenesis. The research focuses on understanding how single-stranded DNA at replication forks may be preferentially mutagenized by formaldehyde, a known class I carcinogen. The study aims to identify individuals at higher risk for formaldehyde-induced carcinogenesis, particularly those with DNA repair and replication disorders associated with abundant single-stranded DNA. The work is funded by the National Cancer Institute and conducted by the Medical University of South Carolina.

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