NIH Reporter #1R21AI191151-01

Biosensor Development for Rapid Detection of Borrelia Infections (NIAID)

This opportunity involves the National Institute of Allergy and Infectious Diseases (NIAID) funding the development of a biosensor for rapid detection of Borrelia burgdorferi, the bacteria responsible for Lyme Disease. - Government Buyer: - National Institute of Allergy and Infectious Diseases (NIAID), part of the US government - OEMs and Vendors: - No specific OEMs named for the biosensor device - BioTech Solutions and SensorTech Inc. listed as bidders - Products/Services Requested: - Development of a highly sensitive biosensor device using covalent probes attached to epitaxial graphene - Testing of 3,000 samples (blood, urine, synovial fluid) for Borrelia burgdorferi using the biosensor - Unique/Notable Requirements: - Biosensor must detect BbHtrA protease as a biomarker - Compliance with NIH guidelines and relevant licensing/classification requirements - Project valued at $436,236 - Technical Approach: - Use of covalent probes on epitaxial graphene for biomarker detection - Focus on sensitivity and rapid detection in multiple sample types

Description

This project aims to develop a highly sensitive biosensor to detect active Borrelia burgdorferi infections, the causative agent of Lyme Disease. The biosensor will target the Bb protease, high temperature requirement A (BbHtrA), as a biomarker. The device will utilize covalent probes attached to epitaxial graphene to detect the bacteria in blood, urine, and synovial fluid samples. The project duration is from August 1, 2025 to July 31, 2027, with an estimated value of $436,236. The funding agency is the National Institute of Allergy and Infectious Diseases (NIAID).

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