NIH Reporter #PA-23-272

Research Services for Structural Dynamics of APOBEC Inhibition in Cancer Therapeutics

This opportunity is issued by the National Cancer Institute (NCI) in partnership with the University of Minnesota, seeking research services to investigate the structural dynamics of APOBEC3A and APOBEC3B inhibition for cancer therapeutics. - Government Buyer: - National Cancer Institute (NCI) - Collaboration with University of Minnesota - Products/Services Requested: - Research services focused on the structural mechanisms of APOBEC3A and APOBEC3B inhibition - Utilization of cryo-electron microscopy (cryo-EM) and nanobody interactions - OEMs and Vendors: - No specific OEMs or vendors are named in the solicitation - Unique or Notable Requirements: - Emphasis on advanced structural biology techniques (cryo-EM, nanobody interactions) - Research aims to support the development of cancer therapeutics - No part numbers, product quantities, or unique equipment specified - Estimated contract value: $35,827

Description

This is a research project focusing on structural mechanisms of APOBEC3A and APOBEC3B inhibition using cryo-EM and nanobodies, with a focus on cancer therapeutics. The project is funded by the NIH and involves the University of Minnesota and the National Cancer Institute. The research aims to understand the structural dynamics of APOBEC inhibition to aid in cancer-related research.

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