NIH Reporter #1R21AI188373-01

Grant Award for Ebola Virus Mouse Model Research (NIH/NIAID to Mayo Clinic)

This opportunity involves a multiyear grant award from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, to Mayo Clinic Rochester for advanced Ebola virus research. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Allergy and Infectious Diseases (NIAID) - Awardee: - Mayo Clinic Rochester - Products/Services Requested: - Development of a new mouse model for Ebola virus infection - Use of transcription and replication virus-like particles (trVLPs) with helper proteins expressed in trans - In vivo study of Ebola virus under BSL-2 conditions (lower biosafety level) - Unique/Notable Requirements: - Enables Ebola research without producing infectious virus, allowing work outside of high-containment (BSL-4) labs - Supports broader testing of vaccines and therapeutics for Ebola - No specific OEMs or commercial products are mentioned; the focus is on biomedical research services

Description

This NIH grant opportunity seeks to develop a new mouse model for Ebola virus infection using safer virus-like particles, enabling broader research for vaccines and therapeutics. The project aims to generate murine models with transcription and replication virus-like particles (trVLPs) to study Ebola virus in vivo under BSL-2 conditions without generating infectious virus. This approach facilitates antiviral response assessment and testing of vaccines and inhibitors. The research addresses the high containment limitations currently restricting Ebola virus studies.

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