NIH Reporter #5R01DK135573-03

NIH NIDDK Solicitation: Research on Renal Denervation for Polycystic Kidney Disease

This opportunity is issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the NIH, seeking research proposals on renal denervation as a treatment for Polycystic Kidney Disease (PKD). - Government Buyer: - National Institutes of Health (NIH) - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) - OEMs and Vendors: - No specific OEMs or vendors are named in the solicitation - Products/Services Requested: - Research services to study the mechanisms and mediators of renal denervation in PKD - Use of animal models and molecular biology techniques - Investigation of therapeutic interventions, with a focus on the FDA-approved drug Tolvaptan - Unique or Notable Requirements: - Expertise in animal models and molecular biology - Experience with Tolvaptan - Collaboration with the University of Minnesota, Minneapolis, MN - No specific part numbers or product quantities are listed - The opportunity is open for research applications and focuses on advancing understanding of PKD progression and treatment options

Description

This project aims to elucidate the role of renal nerves in the progression of Polycystic Kidney Disease (PKD) and explore potential therapeutic interventions involving renal denervation. The study involves animal models and investigates molecular mechanisms, with a focus on the interaction with the FDA-approved drug Tolvaptan. The research is conducted by the University of Minnesota under the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the NIH. The solicitation is active and open for applications.

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