NIH Reporter #5R01DA058114-03

NIDA Awards Research Study on Neurobehavioral Effects of Childhood mTBI and Addiction Risk

This opportunity involves a research award from the National Institute on Drug Abuse (NIDA), part of the US National Institutes of Health, to Washington University, Department of Psychiatry, for a study on the neurobehavioral consequences of mild traumatic brain injury (mTBI) and addiction risk. - Government Buyer: - National Institute on Drug Abuse (NIDA), National Institutes of Health (NIH) - Awardee: - Washington University, Department of Psychiatry, Saint Louis, MO - Products/Services Requested: - Longitudinal research study using a cotwin-control design with monozygotic twins - Utilization of multimodal neuroimaging tools, including MRI and EEG - Unique/Notable Requirements: - Focus on long-term neurobehavioral effects of childhood mTBI - Examination of the relationship between mTBI and addiction risk - Use of advanced neuroimaging and a cotwin-control methodology - No specific OEMs, vendors, part numbers, or product quantities are identified in the opportunity - The research aims to address critical gaps in understanding mTBI and inform future treatment, rehabilitation, and prevention strategies

Description

This project aims to identify long-term neurobehavioral consequences of childhood mild traumatic brain injury (mTBI) and examine their contribution to addiction risk using a cotwin-control design, longitudinal follow-up, and multimodal neuroimaging tools. The study addresses methodological challenges by distinguishing effects of mTBI from pre-existing neurocognitive deficits and substance use confounders. It involves multimodal neuroimaging including MRI and EEG and focuses on monozygotic twins. The research seeks to improve understanding of mTBI's impact on brain structure and function and inform targeted treatments and prevention programs.

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