NIH Reporter #5R16DE034585-02

Award for Research on Fringe Regulation of Notch Signaling in Osteoclasts

This award notice announces that Eastern Washington University has received funding from the National Institute of Dental and Craniofacial Research (NIDCR), a part of the National Institutes of Health (NIH), for research on the regulation of Notch signaling in osteoclasts. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Dental and Craniofacial Research (NIDCR) - Awardee: - Eastern Washington University - Project Title: - 'Fringe regulation of Notch signaling in osteoclasts' - Scope of Work: - Investigate how glycosylation by Fringe family enzymes affects Notch receptor activation and osteoclastogenesis - Employ targeted overexpression, knockdown, and RNA sequencing techniques - Advance understanding of bone biology and signaling pathways - Potential implications for therapies targeting bone loss diseases - Products/Services: - No specific OEMs, vendors, or commercial products are mentioned - No equipment or material procurement is identified in this award - Award Value: - $120,204 - Notable Requirements: - Focus on molecular biology research methods - Emphasis on scientific discovery rather than acquisition of goods or commercial services

Description

This project aims to expand understanding of how decoration of Notch signaling receptors with sugars influences osteoclast formation and function. It will study the effects of Fringe family glycosylation on Notch receptor activation and osteoclast activity, with potential implications for developing new bone-preserving therapies. The project will investigate how Fringe-catalyzed glycosylation affects Notch receptor activation and osteoclastogenesis, using targeted overexpression, knockdown, and RNA sequencing. This research is part of NIH's efforts to understand bone biology and signaling pathways, with potential therapeutic implications for bone loss diseases.

View original listing