NIH Reporter #1R01AI195754-01

NIAID Awards Grant for Research on LPMOs in Pseudomonas aeruginosa

This opportunity involves a research grant awarded by the National Institute of Allergy and Infectious Diseases (NIAID) to the University of California, San Diego for studying Lytic Polysaccharide Monooxygenases (LPMOs) in Pseudomonas aeruginosa. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Allergy and Infectious Diseases (NIAID) - OEMs and Vendors: - No specific OEMs are named - Prospective vendors mentioned: BioResearch Inc., GenTech Labs - Products/Services Requested: - Research on LPMOs in Pseudomonas aeruginosa (5 years) - Development of monoclonal antibodies (10 units) - Proteomics analysis (3 samples) - Unique/Notable Requirements: - Focus on elucidating molecular mechanisms of bacterial pathogenesis - Development of potential therapeutic strategies - Emphasis on both research and deliverable services (antibodies, proteomics) - Estimated contract value: $449,578

Description

This NIH grant opportunity focuses on researching the role of Lytic Polysaccharide Monooxygenases (LPMOs) in the virulence and immunity of the bacterium Pseudomonas aeruginosa. The project aims to investigate the molecular mechanisms of LPMOs, identify host binding partners for the LPMO chitin-binding protein D (CbpD), and assess its enzymatic impact on host-pathogen interactions. The research includes developing monoclonal antibodies and conducting proteomics analysis to better understand bacterial pathogenesis and potential therapeutic strategies.

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