NIH Reporter #5IK6BX006479-03

Research Grant for Bone Fragility in Veterans with CKD – BLRD Career Scientist Award

The Department of Veterans Affairs (VA), RLR VA Medical Center in Indianapolis, is seeking research proposals under the BLRD Research Career Scientist Award focused on bone fragility in veterans with chronic kidney disease (CKD). - Government Buyer: - Department of Veterans Affairs (VA) - RLR VA Medical Center, Indianapolis - Scope of Work: - Research to understand causes of bone fragility in veterans with CKD - Develop approaches to minimize fracture risk, including: - Investigating reversal of cortical porosity - Enhancing bone material quality to improve mechanical properties - Using microRNA as biomarkers to differentiate skeletal diseases - Aim to develop clinical regimens and precision medicine strategies to reduce skeletal burden and improve quality of life for veterans with CKD - Products/Services Requested: - No specific products, part numbers, or equipment are requested - This is a research grant opportunity, not a procurement of goods - Unique/Notable Requirements: - Emphasis on translational research and clinical application - Focus on precision medicine and biomarker development - No OEMs or vendors specified; open to qualified research applicants

Description

This project focuses on research to understand the causes of bone fragility in veterans with chronic kidney disease (CKD) and to develop approaches to minimize fracture risk. The research aims to improve health outcomes by studying bone loss and fracture risk, which are elevated in the veteran population with CKD. The work includes investigating reversal of cortical porosity and using microRNA as biomarkers for skeletal disease differentiation. The goal is to develop clinical regimens to reduce skeletal burden and improve quality of life for veterans with CKD.

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