NIH Reporter #1U01DA064170-01

NIDA Research Award: Neurodevelopmental Impact of Maternal Opioid Use in Rodent Models

This opportunity involves a research award from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, to Washington University in Saint Louis, MO, focused on the neurodevelopmental effects of maternal opioid use in rodent models. - Government Buyer: - National Institute on Drug Abuse (NIDA), National Institutes of Health - Primary Vendor: - Washington University, Saint Louis, MO - Products and Services Requested: - Research and data analysis on neurodevelopmental impact of opioid exposure in rodents - MRI imaging of rodent brains (10 units) - Behavioral testing of rodent offspring - Notable Requirements: - Use of murine (rodent) models to study long-term effects of maternal opioid (oxycodone) use - Investigation of opioid maintenance therapies (methadone, buprenorphine) and withdrawal mitigation strategies (methadone, morphine, buprenorphine) - MRI imaging to correlate brain structural changes - Examination of GABAergic projections in reward circuits - Analysis of neuro-behavioral development and reward processing disruptions - No specific OEMs are listed; the focus is on research methodology and technical requirements rather than branded equipment.

Description

This NIH grant opportunity seeks research on the long-term impact of in utero oxycodone exposure and clinical treatment strategies on neuro-behavioral development in rodent offspring. The project will use a murine model to investigate effects of opioid maintenance therapy and withdrawal mitigation on brain structure, volume, and reward processing. The study aims to evaluate therapies such as methadone and buprenorphine and their impact on neurodevelopmental outcomes. Research includes behavioral testing, MRI imaging, and analysis of reward circuit disruptions.

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