SAM #80NSSC26936794Q

NASA Sole Source Procurement: Multiorgan Microphysiological Platform for Radiation Injury and Countermeasure Evaluation

NASA is seeking the development and evaluation of a human multiorgan microphysiological platform to study radiation-induced injury and test countermeasures. - Government Buyer: - National Aeronautics and Space Administration (NASA) - NASA Shared Services Center (NSSC) - Johnson Space Center - OEMs and Vendors: - Biopico Systems Inc. (sole source contractor and platform developer) - Products/Services Requested: - PRISM CMEVALUATE human multiorgan microphysiological platform - Integrates cerebral, cardiac, liver, and endothelial tissues under recirculating flow - Models effects of 0.5, 1, and 2 Gy radiation exposure - Radiation dose-response datasets - Quantitative analysis of ROS, H2AX/53BP1 DNA damage, cytokines, viability, and tissue-specific functional markers - Evaluation of candidate radiation countermeasure compounds - Compounds: NAC, Metformin, Fisetin, Amifostine - Final analyzed dataset and summary report for NASA data submission - Unique/Notable Requirements: - Sole source procurement to Biopico Systems Inc. - Platform must enable functional assays and quantitative analysis across multiple human tissue types - Deliverables include comprehensive datasets and a final report suitable for NASA data submission

Description

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