Opportunity
Simpler Grants.gov #RFA-RM-27-003
NIH Director’s Transformative Research Award for Innovative Biomedical Science
Buyer
National Institutes of Health
Posted
June 29, 2026
Respond By
September 03, 2026
Identifier
RFA-RM-27-003
NAICS
541715
The National Institutes of Health (NIH) is inviting applications for the Director's Transformative Research Award, part of the High-Risk, High-Reward Research (HRHR) program under the NIH Common Fund. - Government Buyer: - National Institutes of Health (NIH) - NIH Common Fund, High-Risk, High-Reward Research (HRHR) program - Purpose: - Supports individual scientists or groups proposing bold, innovative, and potentially paradigm-shifting research in any area of biomedical science - Projects may be basic, translational, or clinical in nature - Key Requirements: - Proposals must demonstrate potential for major scientific impact, such as creating new paradigms, improving clinical approaches, or developing transformative technologies - No preliminary data required - Open to U.S.-based organizations (government, nonprofit, business, educational institutions); foreign organizations not eligible, but foreign components allowed per NIH policy - Funding Details: - Estimated total funding: $8,000,000 - Approximately 7 awards expected - No specific OEMs, vendors, or products are requested, as this is a grant for research proposals, not a procurement of goods or services
Description
The NIH Director's Transformative Research Award supports individual scientists or groups proposing bold, groundbreaking, and innovative research with the potential to create new scientific paradigms or develop transformative technologies. Applications in any biomedical science area are welcome, including basic, translational, or clinical research. Projects must demonstrate a compelling potential to produce a major impact relevant to the NIH. No preliminary data are required.