Opportunity
SAM #75N98026Q00583
NIH NIDDK Solicitation for PAXgene RNA Extraction and Agilent Quality Control Services
Buyer
NIH Office of Logistics and Acquisition Operations
Posted
June 10, 2026
Respond By
June 20, 2026
Identifier
75N98026Q00583
NAICS
541714, 541380
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health (NIH), is seeking specialized laboratory services for research sample processing. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) - OEMs Highlighted: - PAXgene (for RNA extraction tubes and kits) - Agilent (for quality control instrumentation) - Requested Services: - Extraction of ribonucleic acid (RNA) from 122 PAXgene tube units collected from 50 clinical participants - Quantitation and normalization of RNA samples to ensure consistent concentrations - DNase treatment to remove DNA contaminants - Quality control and integrity assessment using Agilent instrumentation - Aliquoting of samples (up to 21 aliquots per sample) - Secure frozen storage and shipment of samples on dry ice - Complete documentation, traceability, and chain-of-custody records - Repository management and provision of certificates of analysis and shipment tracking - Notable Requirements: - Use of validated protocols for high-quality RNA extraction - Strict quality control acceptance criteria - Maintenance of specimen integrity throughout processing and storage - Support for transcriptomic analysis and gene expression profiling
Description
Requirements
3.0 OBJECTIVE
The objective of this requirement is to procure PAXgene ribonucleic acid extraction, quantitation, normalization, Agilent quality control, and aliquoting services for samples collected from 50 clinical participants in support of ongoing NIDDK clinical protocol research and downstream transcriptomic analysis.
These services are necessary to support research involving gene expression profiling, molecular characterization of biospecimens, identification of disease mechanisms, and evaluation of potential therapeutic targets through transcriptomic analysis.
4.0 CONTRACTOR REQUIREMENTS
The contractor shall provide PAXgene ribonucleic acid extraction and aliquoting services for 122 PAXgene tube units collected from 50 clinical participants. Services shall include ribonucleic acid extraction, quantitation, normalization, Agilent quality control testing, aliquoting, frozen storage, and shipment on dry ice.
The contractor shall perform high-quality ribonucleic acid extraction from PAXgene tubes using validated protocols and established laboratory procedures.
The contractor shall perform ribonucleic acid quantitation and normalization to ensure consistent sample concentrations suitable for downstream transcriptomic analysis.
The contractor shall perform deoxyribonuclease (DNase) treatment to remove genomic deoxyribonucleic acid contaminants and ensure clean ribonucleic acid preparations.
The contractor shall perform ribonucleic acid integrity and quality assessments using Agilent instrumentation to verify sample suitability for downstream transcriptomic analysis.
The contractor shall aliquot up to twenty-one (21) aliquots per sample and provide secure frozen storage conditions to prevent sample degradation prior to shipment.
The contractor shall maintain complete documentation and traceability records, including logging of processing steps and sample status throughout all stages of handling and processing.
Quality Control
Upon receipt, all specimens shall meet the contractor’s established quality control acceptance criteria for processing.
The contractor shall inspect all specimens upon receipt and immediately notify NIDDK of any compromised, damaged, or nonconforming specimens requiring replacement.
The contractor shall verify specimen integrity upon delivery through visual inspection and temperature monitoring procedures.
Repository Management
The contractor shall provide certificates of analysis and donor documentation for each specimen, as applicable.
The contractor shall provide shipping documentation and chain-of-custody records to NIDDK upon delivery.
The contractor shall ensure specimens are maintained and stored under appropriate frozen conditions throughout handling, storage, and shipment activities.
The contractor shall provide order status updates and shipment tracking information to designated NIDDK personnel throughout the period of performance.