Simpler Grants.gov #U01

NIH Forecast: GREGoRi Innovation Projects for Rare Genetic Disorder Research

This opportunity is a forecasted research funding announcement from the National Institutes of Health (NIH), specifically the National Human Genome Research Institute (NHGRI). - The initiative seeks proof of concept studies for novel strategies to identify genes or variants underlying rare genetic disorders - Focus is on moving beyond traditional DNA sequencing methods - Encourages use of emerging molecular technologies such as: - Multi-omics - RNA-seq - Methylation analysis - Technologies that show promise may be integrated into the Technology Integration Center - No specific OEMs, vendors, or commercial products are named, as the focus is on research methodologies and technology development - Eligible applicants include businesses, government entities, nonprofits, and educational institutions - No product or service purchase quantities are specified, as this is a research grant forecast - Unique requirement: Emphasis on innovative, non-traditional molecular approaches for rare disease gene discovery

Description

This funding opportunity supports the continuation of the Consortium to Study Chronic Kidney Disease of UnceRtain Etiology (CKDu) in Agricultural Communities (CURE). The research aims to understand the causes and progression of CKDu, a disease causing kidney failure in rural areas of many low and middle income countries, with implications for kidney health in the U.S. The Renal and Environmental Science Core will provide support and leadership in discovery science, collaborating with consortium members to explore etiologies, exposures, therapeutic targets, and public health interventions. The consortium will also serve as a resource for ancillary studies.

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