Simpler Grants.gov #360666

NIH Forecast: Advanced 3-D Tissue Model Development for Drug Screening

This opportunity is a forecasted funding announcement from the National Institutes of Health (NIH), specifically the National Center for Advancing Translational Sciences (NCATS), for advanced 3-D tissue model development for drug screening. - Government Buyer: - National Institutes of Health (NIH) - National Center for Advancing Translational Sciences (NCATS) - Products/Services Requested: - Research and development services to create, validate, and demonstrate advanced 3-D tissue models for high-throughput drug screening - Models must mimic structural, biochemical, and mechanical properties of tissues - Focus on non-animal, physiologically relevant models for testing small molecules and biologics - Unique/Notable Requirements: - Mandatory use of NCATS 3-D Bioprinting laboratory expertise and infrastructure - Models should balance physiological complexity with robustness and reliability - No specific OEMs, vendors, products, or part numbers are named - Broad eligibility for applicants, but foreign organizations are excluded - Estimated Funding: - $1,600,000 total, with two expected awards

Description

The National Institutes of Health (NIH) intends to solicit applications to develop, validate, and demonstrate advanced 3-D tissue models for testing the efficacy of therapeutic modalities such as small molecules and biologics. The goal is to accelerate the discovery and development of new therapeutics across various diseases using non-animal models that mimic tissue properties relevant to drug behavior. Applicants must utilize the 3-D modeling and drug screening expertise at the NCATS 3-D Bioprinting laboratory. The models should balance complexity for physiological relevance with simplicity for robustness and suitability in drug screening.

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