University of Missouri Ionwave #26-0023 Addendum 1

University of Missouri Solicits cGMP Hot Cell Systems for Radioisotope Science Center

The University of Missouri is seeking proposals for the design, manufacture, delivery, installation, and validation of advanced hot cell systems for its new Radioisotope Science Center at the University of Missouri Research Reactor (MURR). - Government Buyer: - University of Missouri, University of Missouri Research Reactor (MURR), UM Procurement - Products/Systems Requested: - Three hot cell systems: - One three-chambered hot cell for bulk radiochemical production - One two-chambered hot cell for auxiliary support functions - One two-chambered hot cell for research-grade isotope production and R&D - Hot cell system features: - cGMP-compliant equipment (EU/US standards) - Seismic qualification - Shielded liquid transfer lines - Expandable 2-cell system (potential to add a third cell) - Shielded containers (6 units) for samples and waste, fitting 5 mL v-bottom vials and 500–1000 mL bottles - High-capacity casks/adaptors (6 units) with lead shielding and removable design - Autoclave integration with 50 mm lead shielding and external controls - Accommodation for chromatography columns and vials with specified size/weight capacities - Services Requested: - Comprehensive design, installation, and validation services for all hot cell systems - Compliance with cGMP, OSHA, CE, and other safety/quality standards - Performance guarantees and binding delivery/installation timelines - Notable Requirements: - Vendors must demonstrate technical expertise with at least three similar installations - Detailed User Requirements Specifications (URS) must be met - System must allow for future expansion and integration - Delivery and installation must be completed within a specified 6-month window - Proposals must include technical and operational details, and options for additional units/services - No specific OEMs or vendors are named in the solicitation; procurement is open to qualified suppliers able to meet all requirements.

Description

The University of Missouri is soliciting proposals for the furnishing and delivery of hot cells for the Radioisotope Science Center. The project involves designing, manufacturing, delivering, installing, and validating three hot cell systems to support cGMP production of novel radioisotopes and research and development of new radioisotope manufacturing processes. Qualified suppliers must meet mandatory requirements including cGMP compliance, quality assurance, technical expertise, delivery timeline commitments, performance guarantees, and safety compliance. Proposals must be submitted via the University of Missouri System's electronic bidding platform by October 2, 2025.

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