SAM #NIH-NOI-26-PCA-NIA-01205

Sole Source Contract for Expansion and Distribution of iNDI FA13.1J iPSC Cell Lines for Alzheimer’s Research

This opportunity is a sole source contract from NIH NIA CARD for the expansion, quality control, curation, biobanking, and public distribution of up to 936 isogenic Alzheimer's disease and related dementias (ADRD) induced pluripotent stem cell (iPSC) lines. - Agency: Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Institute on Aging (NIA), Center for Alzheimer’s Disease and Related Dementias (CARD) - Sole source vendor: The Jackson Laboratory - Products: - 486 FA13.1J female SNV iPSC lines - 450 iPSC lines from 25 high-priority SNV trios (across six additional lines) - Services: - Expansion and quality control of all iPSC lines (viability, viral/microbial testing, gene edit confirmation, karyotyping, pluripotency profiling, sterility testing) - Curation, biobanking, and public distribution via a contractor-hosted website/platform - Product and web content creation for each cell line - All work must follow current iNDI protocols and ensure continuity with existing iNDI resources - Contract structure: Base year (Sept 1, 2026 - Aug 31, 2027) plus three option years (through Aug 31, 2030) - Performance at contractor facility; annual renewal possible - Other vendors may submit capability statements if they can meet all requirements - Estimated contract value: $2,000,000 - $4,000,000

Technical details: - Cell lines are generated using CRISPR-Cas12a technology - Quality control includes comprehensive testing and profiling - Distribution requires a dedicated website with uploaded QC data and design files - The Jackson Laboratory is cited as the only source with the necessary infrastructure and continuity for iNDI resources

Description

SPECIAL NOTICE NOTICE OF INTENT TO AWARD A SOLE SOURCE CONTRACT

Agency: Department of Health and Human Services (HHS), National Institutes of Health (NIH), National Institute on Aging (NIA) Office: Center for Alzheimer’s Disease and Related Dementias (CARD) Notice Type: Special Notice Notice Number: NIH-NOI-26-PCA-NIA-01205

Title: Notice of Intent to Sole Source – iNDI FA13.1J Cell Lines Expansion and Distribution for the iPSC Neurodegenerative Disease Initiative (iNDI) Project NAICS Code: 325414 – Biological Product (except Diagnostic) Manufacturing PSC: 6550 – In Vitro Diagnostic Substances, Reagents, Test Kits and Sets

Description

This is a notice of intent to award a sole source contract and is not a request for competitive quotations, proposals, or bids. The National Institute on Aging (NIA), Center for Alzheimer’s Disease and Related Dementias (CARD), intends to negotiate and award a firm-fixed-price contract to:

The Jackson Laboratory 600 Main Street Bar Harbor, ME 04609 UEI: XR6LMXNKDJJ1

for iNDI FA13.1J Cell Lines Expansion and Distribution for the iPSC Neurodegenerative Disease Initiative (iNDI) Project.

The anticipated contract will provide for the expansion, quality control, curation, biobanking, and distribution of up to 936 isogenic Alzheimer’s disease and related dementias (ADRD) induced pluripotent stem cell (iPSC) lines in support of the iPSC Neurodegenerative Disease Initiative (iNDI). The requirement includes:

FA13.1J female SNV lines totaling 486 iPSC lines; 25 high-priority SNV trios across six additional iPSC lines totaling 450 iPSC lines; expansion and quality control in accordance with current iNDI protocols; product and web content creation for each iPSC line; and public distribution of cell lines through an established contractor-hosted website/platform.

The statutory authority for this acquisition is 41 U.S.C. 1901, as implemented by FAR 13.501(a)(1)(ii), based on the circumstances described in FAR 6.302-1, Only One Responsible Source and No Other Supplies or Services Will Satisfy Agency Requirements.

The Government’s market research included review of the prior sources sought notice posted on SAM.gov under Notice ID 75N95025Q00209-SBSS, review of prior NIH awards for similar iNDI requirements, and review of commercially available information regarding potential sources. Based on that market research, The Jackson Laboratory is the only known source capable of providing the specific iNDI FA13.1J iPSC cell lines and associated expansion, quality control, curation, and distribution services required for this acquisition. The Jackson Laboratory also maintains the existing iNDI distribution infrastructure and has successfully performed prior related iNDI requirements for NIH.

Period of Performance

Base Year: September 1, 2026 – August 31, 2027 Option Year 1: September 1, 2027 – August 31, 2028 Option Year 2: September 1, 2028 – August 31, 2029 Option Year 3: September 1, 2029 – August 31, 2030

Place of Performance

The principal place of performance is the contractor’s facility.

Responses

This notice is not a solicitation. However, any responsible source that believes it can satisfy the Government’s requirement may submit a capability statement for the Government’s consideration. Capability statements shall clearly demonstrate the ability to provide:

the specific iNDI FA13.1J cell lines and associated iNDI lines required under this acquisition; expansion and quality control in accordance with current iNDI protocols; product and web content creation for each iPSC line; public distribution through an established contractor-hosted platform; and continuity sufficient to preserve comparability with existing iNDI resources and prior work.

Responses shall include, at a minimum:

Company name UEI and CAGE Code, if applicable Business size and socioeconomic status Technical point of contact, including name, title, telephone number, and email address Narrative capability statement addressing the requirements above Relevant past performance information for similar efforts

Responses must be submitted electronically to the point(s) of contact below no later than June 23, 2026, 11:00 am EST. Responses received after the stated deadline may not be considered.

The Government will review all timely responses solely for the purpose of determining whether to conduct a competitive procurement. A determination by the Government not to compete this requirement, based upon responses to this notice, is solely within the discretion of the Government. The Government will not be responsible for any costs incurred by respondents in preparing or submitting a response.

Point(s) of Contact

Primary Point of Contact: Linda Smith, Contracting Officer, linda.smith2@nih.gov

Secondary Point of Contact: Danielle Tines, Procurement Technician, danielle.tines@nih.gov

View original listing