Opportunity

SAM #DARPA-SN-26-89

DARPA BTO Solicitation for Non-Optical, High-Speed Protein Control Tools

Buyer

DEF ADVANCED RESEARCH PROJECTS AGCY

Posted

June 08, 2026

Respond By

December 08, 2026

Identifier

DARPA-SN-26-89

NAICS

541714, 541715

This opportunity is a DARPA Biological Technologies Office (BTO) solicitation for innovative research and development: - Agency: Defense Advanced Research Projects Agency (DARPA), Biological Technologies Office (BTO) - Objective: Develop rapidly switchable, non-optogenetic protein domains for real-time cellular control - Focus on molecular tools enabling massless information transfer across cell membranes - Intended to supplement and enhance existing synthetic biology platforms - Requirements: - Solutions must not rely on optical (light-based) methods - Emphasis on rapid switching capability and compatibility with synthetic biology - Open to novel, robust, and versatile approaches - No specific OEMs, vendors, part numbers, or quantities are identified - Commercial opportunity for research organizations, biotech firms, and synthetic biology innovators - No attachments or detailed line items provided - Period of performance and contract value are not specified

Description

DARPA BTO will be actively “shopping” the ERIS Marketplace for innovative, post-competitive, awardable solutions that address the need for a new class of rapidly switchable, non-optogenetic protein domains for real-time cellular control. This effort seeks to develop a robust and versatile molecular tool for massless information transfer across a cell membrane, intended to supplement existing synthetic biology platforms.

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