SAM #75N98026Q00477

NIH Procurement of Oxford Nanopore PromethION Flow Cells and Sequencing Kits for Alzheimer's Research

This procurement supports advanced Alzheimer's research at NIH's Center for Alzheimer's Disease and Related Dementias (CARD): - Government Buyer: - National Institutes of Health (NIH), Office of the Director, Office of Logistics and Acquisition Operations - OEM Highlight: - Oxford Nanopore Technologies Inc. is the sole manufacturer of the required products - Vendors and Products Requested: - PromethION Flow Cells (Oxford Nanopore, P/N FLO-PRO114M) - Quantity: 72 units - Enables high-accuracy long-read sequencing on PromethION 48 infrastructure - cDNA-PCR Sequencing Kit V14 (Oxford Nanopore, P/N SQK-LSK114-XL) - Quantity: 48 kits - Supports cDNA preparation for nanopore sequencing, compatible with R10.4.1 chemistry - Purpose and Unique Requirements: - Products are proprietary and required for compatibility with CARD's existing PromethION 48 sequencers and bioinformatics pipelines - Reagents will be used for long-read RNA sequencing of 250 ROSMAP brain samples to study transcript-level differences in Alzheimer's disease - Kits must enable direct comparison with previous long-read whole-genome sequencing data - Place of Performance and Delivery: - Delivery to National Institute on Aging Center for Alzheimer's Disease and Related Dementias, Rockville, MD - Contracting managed by NIH Office of Logistics and Acquisition Operations, Bethesda, MD - Period of Performance: - 6 months from award

Description

(i) This is a combined synopsis/solicitation for commercial items prepared in accordance with the format in FAR Subpart 12.6, as supplemented with additional information included in this notice. This announcement constitutes the only solicitation; proposals are being requested, and a separate written solicitation will not be issued.(ii) The solicitation number is 75N98026Q00477. This solicitation is issued as a Notice of Intent (NOI) for a non-competitive combined synopsis/solicitation to award a contract or purchase order without providing for full and open competition (brand-name).This acquisition is conducted under the authority of FAR 12.603, Streamlined Solicitation for Commercial Products or Commercial Services, and is not expected to exceed the simplified acquisition threshold. Additional authority includes 41 U.S.C. 1901 and FAR 6.302-3(a)(2)(ii).The National Institutes of Health (NIH), Office of the Director, Office of Acquisitions, intends to negotiate and award a Firm-Fixed-Price purchase order on a non-competitive basis to Oxford Nanopore Technologies Inc., One Kendall Square, Building 1400, Suite 14-305, Cambridge, MA 02139 for PromethION flow cells and cDNA-PCR sequencing kits required to support the National Institute on Aging's Center for Alzheimer's Disease and Related Dementias (CARD) long-read RNA sequencing project on ROSMAP brain samples. Oxford Nanopore Technologies Inc. is the sole manufacturer of the proprietary flow cells (FLO-PRO114M) and cDNA-PCR Sequencing Kit V14 (SQK-LSK114-XL) required to operate CARD's existing PromethION 48 sequencing infrastructure and to enable direct matched comparison with previously generated long-read whole-genome sequencing data on the same ROSMAP samples.

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