SAM #75N98026Q00434

NIH Procurement of Multisizer 4e Coulter Counter and Accessories

The National Institutes of Health Office of Logistics and Acquisition Operations (NIH OLAO), under the Department of Health and Human Services, is seeking to procure a Multisizer 4e Coulter Counter for clinical research applications. - Government Buyer: - National Institutes of Health (NIH), Office of Logistics and Acquisition Operations (OLAO) - OEM Highlight: - Coulter (manufacturer of the Multisizer 4e Coulter Counter) - Products and Quantities: - Multisizer 4e Coulter Counter (1 unit) - Utilizes the Coulter method with patented digital pulse processing - Features include automatic aperture blockage detection and clearing, barcode scanner, fluid level monitoring, selectable stirrer speed/direction, and a particle sizing range of 0.2–1,600 micrometers - Supports up to 400 size classes/channels, time-stamped pulses, multiple counting modes, and real-time volume change detection - Accessories: - Size aperture tubes (100uM and 400uM; supports 10uM–2000uM) - Beakers (100/200mL) and accuvettes - Isoton II Diluent and Coulter Clenz solutions (with spigot assemblies) - Mixed Standards Kit (L2, L5, L10, L20, L40) - 300uM Particle Standard - Installation service for the instrument and accessories - Unique/Notable Requirements: - Instrument must provide measurement linearity, dynamic range, and accurate determination of sample cell number, size, distribution, and concentration - Must deliver detailed particle count and sizing data, support clinical research protocols, and include all necessary calibration and verification standards - Place of Performance: - NIH facilities in Bethesda, Maryland

Description

The required Multisizer provides improved functionality and analysis capabilities, in addition to allowing continued measurement of cell size, counts, and distribution using the Coulter method across multiple clinical research study protocols. 

                                                  Specifications & Requirements

                        The product shall include/use: 

Coulter method of measurement using patented digital pulse processing technology 

Automatic aperture blockage detection and clearing during runs and sample analysis 

Code scanner to scan bar codes on samples, electrolytes, aperture tubes, and sample beakers 

Fluid level monitoring for solutions and waste 

Selectable stirrer speed and direction 

Particle sizing range: 0.2 – 1,600uM 

Measurement range: 2 – 80% of aperture size 

Measurement linearity: Diameter ± 1%, Volume ± 3% 

Dynamic range (accuracy): 1:40 (diameter), 1:64,000 (volume) 

Accurate determination of sample cell number, size, distribution, and concentration 

Particle count, sizing, and volume distribution data, including diameter, volume, and area of number, number percent, number per mL, volume, volume percent, volume per mL, surface area, surface area percent, surface area per mL 

Pulse distribution data, including time, sequence and width for pulse height diameter, pulse height volume, pulse height volt, pulse width, pulse area, average pulse height diameter, average pulse height volume and average pulse width. Number distribution by width. 

Up to 400 size classes or channels with the ability to change number of size classes or channels and width and reprocess as needed without having to re-run the samples 

Time-stamped pulses up to 525,000 per single analysis 

Modes for Total Count (up to 500,000 counts), Modal Count (up to 100,000 counts), and Volumetric Count (up to 2000uL) 

Digital Pulse Processor with proprietary high-speed signal digitalization 

Real time detection of volume changes 

Stirrer with ability to adjust stir speed and direction for even particle distribution in sample suspensions 

100uM and 400uM size aperture tubes, with instrument ability to use apertures ranging from 10uM up to 2000uM size as needed, with aperture tube calibration and verification 

100/200mL beakers, with ability to use additional size beakers and accuvettes, as required by the sample type, sample volume, or other need 

Isoton II Diluent and Coulter Clenz solutions for instrument operation and cleaning, and spigot assemblies for both solutions 

Mixed Standards Kit (L2, L5, L10, L20, L40) 

300uM Particle Standard 

Installation 

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