SAM #CBER-2026-134085

FDA Solicitation for Bordetella-Free Baboons for Pertussis Research

The U.S. Food and Drug Administration (FDA), Center for Biologics Evaluation and Research (CBER), is seeking the procurement and delivery of twenty Bordetella-free baboons for pertussis infection and vaccination studies. - Government Buyer: - U.S. Food and Drug Administration (FDA) - Center for Biologics Evaluation and Research (CBER) - Contracting office located at 5630 Fishers Lane, Rockville, MD - OEMs and Vendors: - No specific OEMs or vendors are named in the solicitation - Products Requested: - Twenty (20) six to eight-month-old, Bordetella-free, unvaccinated baboons - Must be certified negative for Bordetella exposure - Examined by a licensed veterinarian - Shipped in compliance with USDA and CBER animal welfare protocols - Delivered in one shipment to FDA/CBER Facility in Silver Spring, Maryland - Unique/Notable Requirements: - Baboons must be Bordetella-free and unvaccinated - Strict health and animal welfare standards must be met - Delivery required within 90 days of contract award - Animals must be suitable for pertussis infection and vaccination studies - Place of Performance and Delivery: - FDA Center for Biologics Evaluation and Research, 10903 New Hampshire Avenue, Bldg. 72 CBER Vivarium, Silver Spring, MD 20993 - Contracting office: 5630 Fishers Lane, Rockville, MD 20857

Description

Pertussis is an acute, highly contagious, potentially life-threatening respiratory disease, caused by the Gram-negative bacterium Bordetella pertussis. The underlying factors leading to the failure of public health measures to control pertussis disease using currently licensed vaccines are poorly understood. A more complete understanding of this disease and of the mechanisms of vaccine-mediated protection is a critical public health need.

The baboon model of pertussis, developed in the laboratories of the Food and Drug Administration (FDA) Center for Biologics Evaluation and Research (CBER), is the only animal model of pertussis that recapitulates the disease as observed in human patients. Refinement of the baboon model to include establishment of infection by means of natural transmission will enable a more refine evaluation of the differences between the licensed acellular pertussis vaccines that fail to prevent infection and the whole cell vaccines that reduce infection. The performance of this study requires the purchase and delivery of twenty, Bordetella-free baboons.

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