Simpler Grants.gov #PAR-28-019

NIH Solicitation for Integrated Human NAMs and SPF Research Model Support for HIV/AIDS Research

This opportunity from the National Institutes of Health (NIH) seeks to advance HIV/AIDS research by integrating human New Approach Methodologies (NAMs) and supporting specific pathogen free (SPF) research models. - Government Buyer: - National Institutes of Health (NIH), Division of Comparative Medicine, Office of Research Infrastructure Programs (ORIP) - OEMs and Vendors: - No specific Original Equipment Manufacturers (OEMs) or vendors are named in the solicitation - Products/Services Requested: - Integration of a NAMs triage and consultation service to identify studies suitable for NAMs and document reductions or replacements in animal model use - Establishment of referral pathways to NAM centers and human tissue resources for collaborative development and benchmarking of HIV-relevant human NAMs - Optional support for HIV human in vitro testing, including standardized procedures, quality control, and user guidance for viral load quantification, drug resistance, and ex vivo susceptibility assays - Support for core SPF colony operations, including management, virologic surveillance, rapid mitigation to preserve SPF status, and high-resolution immunogenetic characterization - Unique or Notable Requirements: - Development of standardized operating procedures and quality control frameworks for NAMs - Rigorous stewardship and benchmarking activities for both human NAMs and in vivo SPF resources - No specific products, part numbers, or purchase quantities are listed; focus is on research infrastructure and service provision - Place of Performance: - National Institutes of Health (NIH)

Description

This funding opportunity supports NIH-funded HIV/AIDS research with two integrated priorities: implementing a NAMs-enabled stewardship framework to reduce or replace specific pathogen free (SPF) in vivo model use where appropriate, and supporting high-quality SPF colony resources for necessary in vivo studies. The NAMs-enabled component includes establishing triage and consultation services, referral pathways to NAM centers, and optional HIV human in vitro testing support. The SPF resource component supports core colony operations, including management, surveillance, and immunogenetic characterization to ensure rigorous study design and resource stewardship.

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