SAM #DARPA-SN-26-66

DARPA RFI: Novel Biomolecule Purification Methods for Universal Platform Development

DARPA's Microsystems Technology Office (MTO) is requesting information from the public about innovative methods for purifying large, complex biomolecules. - Purpose: Inform the development of a universal purification platform for biologically produced proteins and other critical molecules - Focus: Methods that improve specificity, purity, and yield, and reduce reliance on multistep chromatography - Scope: Seeking input on current advances, challenges, and potential new operational capabilities in biomolecule purification - No specific products, part numbers, or vendors are mentioned - This is a Request for Information (RFI) to guide future program development, not a solicitation for goods or services - Responses may influence future procurement opportunities

Location: - Contracting office is DARPA at 675 North Randolph Street, Arlington, VA

Description

The Defense Advanced Research Projects Agency (DARPA) Microsystems Technology Office (MTO) seeks information on novel methods for the purification of large complex molecules that will enable the creation of a universal purification platform capable of separating and recovering multiple large and complex molecules with high specificity, purity, and yield from complex feedstock. It is anticipated that such a platform will decrease the time and complexity of purification and eliminate the need for multistep chromatography processes, which DARPA believes to be the state of the art. In addition, this RFI seeks to understand a) the current advances and challenges in the purification of biologically produced proteins, as well as of other critical biologically produced molecules that could benefit from a novel purification approach, and b) new operational capabilities enabled by novel purification approaches. Responses to this RFI will be used to inform the development of a new program.

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