Simpler Grants.gov #RFA-DA-27-012

NIH Solicitation for Gene-Editing Tools in Nervous System Research

The National Institutes of Health (NIH) is seeking proposals to advance gene-editing tools for nervous system research through its Blueprint Initiative. - Government Buyer: - National Institutes of Health (NIH), Blueprint Initiative - Scope of Work: - Development, optimization, validation, and application of germline and somatic gene-editing approaches - Focus on experimental systems modeling human brain anatomy, circuitry, cognition, behavior, and lifespan - Integration and validation of New Approach Methodologies (NAMs), including human-derived NAMs - Research priorities include complex brain conditions such as autism spectrum disorders and schizophrenia - Applicants must justify model selection for neuroanatomy, circuit function, cognition, behavior, or lifespan phenotyping - Products/Services Requested: - No specific OEMs, vendors, or commercial products are named - Main service is research and development in gene-editing and transgenic model systems - Unique Requirements: - Emphasis on innovative NAMs and their application to human brain disease and function - Broad eligibility: open to government, academic, nonprofit, and business organizations - Place of Performance: - National Institutes of Health (NIH)

Description

The NIH Blueprint Initiative aims to support the development, optimization, validation, and application of germline and somatic transgenic and gene-editing approaches in experimental systems that model key features of human brain anatomy, circuitry, cognition, behavior, and lifespan. This initiative builds on previous marmoset gene-editing infrastructure by integrating New Approach Methodologies (NAMs) with other models to advance understanding of human brain function and disease. Research priorities include developing and validating human-derived NAMs for complex conditions such as autism spectrum disorders and schizophrenia. Appropriate models must be justified for questions involving neuroanatomy, circuit function, cognition, behavior, or lifespan phenotyping related to human brain disease and function.

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