SBIR / STTR #CBD254-012

DoD SBIR Solicitation for Microphysiological Systems and Advanced Chemical/Biological Defense Technologies

This Department of Defense (DoD) Small Business Innovation Research (SBIR) opportunity seeks advanced research and development for chemical and biological defense technologies, with a focus on microphysiological systems for vaccine evaluation. - Government Buyer: - Department of Defense (DoD), Defense Threat Reduction Agency (DTRA), Joint Science and Technology Office for Chemical and Biological Defense (JSTO CBD), Chemical and Biological Technologies Directorate, Medical Division - OEMs and Vendors: - No specific OEMs or vendors are named; the solicitation is open to all qualified small businesses - Products/Services Requested: - Research and development of immune microphysiological systems (iMPS) to assess pretreatment immunogenicity and efficacy (MAGPIE) - In vitro models to replicate human immune responses for vaccine evaluation against high consequence pathogens - Validation against FDA-approved vaccines (Phase I), prediction of novel vaccine performance (Phase II), optimization and off-target assessment (Phase III) - Additional R&D topics include: - PFAS-free regenerable respirator filtration systems - SERS sampling tickets for chemical/biological threat detection - Integrated deployable microsensors for chemical detection - On-demand manufacturing of CBRN sensors - Tactical CB visualization tools (e.g., augmented reality) - Shelf-stable nucleic acid synthesis reagents for field diagnostics - Expeditionary biologics-on-demand protein production systems - Unique or Notable Requirements: - Solutions must be suitable for military operational environments - Emphasis on technologies that accelerate vaccine development and improve warfighter readiness - Compliance with SBIR/STTR program rules, export control, and human/animal subject research regulations - Open to Phase I, II, and II-S proposals with defined funding and period of performance limits

Description

This solicitation seeks proposals for the development of microphysiological systems to assess pretreatment immunogenicity and efficacy. It is part of the Department of Defense's Small Business Innovation Research (SBIR) program under the Chemical and Biological Defense Program (CBD). The project aims to improve defensive capabilities against chemical and biological threats by advancing technologies such as medical pretreatments and diagnostics. The solicitation is open for Phase I, II, and II-S proposals with a response deadline of August 7, 2023.

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