SBIR / STTR #CBD254-010

DoD SBIR: Shelf-Stable Nucleic Acid Synthesis Reagents for Field Diagnostics

The Department of Defense is seeking innovative research and development solutions to advance chemical and biological defense technologies, with a specific focus on shelf-stable nucleic acid synthesis reagents for field-deployable diagnostics. - Government Buyer: - Department of Defense (DoD) - Defense Threat Reduction Agency (DTRA) - Joint Science and Technology Office for Chemical and Biological Defense (JSTO CBD) - Products/Services Requested: - Research and development of shelf-stable nucleic acid synthesis reagents for rapid diagnostic test development in expeditionary and resource-limited environments - Reagents must remain stable at room temperature for at least 12 months - Must function across a temperature range of -20°C to 55°C - Should improve nucleic acid yield and be suitable for military and commercial diagnostic applications - Related R&D topics include: - PFAS-free regenerable respirator filters - SERS sampling tickets for threat detection - Deployable microsensors for chemical detection - On-demand CBRN sensor manufacturing - Tactical CB visualization tools - Portable biologics-on-demand systems - Microphysiological systems for vaccine evaluation - Program Structure and Requirements: - Multi-phase SBIR program: Phase I (feasibility), Phase II (optimization and scale-up), Phase III (commercialization) - Compliance with SBIR and STTR Extension Act of 2022 - Disclosure of foreign nationals involved in the project - Adherence to guidelines for research involving human or animal subjects, and recombinant DNA - No specific OEMs or vendors are named; the opportunity is open to small businesses with innovative R&D capabilities - Notable Requirements: - Emphasis on shelf-stability, temperature resilience, and improved yield for nucleic acid reagents - Solutions must be suitable for far-forward, field, and resource-limited settings - Transition to commercial production and regulatory approval is expected in later phases

Description

This solicitation is for the development of shelf-stable nucleic acid synthesis reagents suitable for field-deployable diagnostics. The project aims to enhance rapid diagnostic capabilities in field conditions. It is part of the Department of Defense's Small Business Innovation Research (SBIR) program focused on chemical and biological defense technologies. Proposals must comply with the terms of the announcement and are subject to evaluation for scientific and technical quality. The program encourages innovative solutions to improve defense against chemical and biological threats.

View original listing