Simpler Grants.gov #RFA-CA-27-017

Pharmacokinetics Resource Laboratory Services for NCI ETCTN Clinical Trials

The National Cancer Institute (NCI), part of the National Institutes of Health, is preparing to release a funding opportunity for a Pharmacokinetics Resource Laboratory to support the Experimental Therapeutics Clinical Trials Network (ETCTN): - Government buyer: - National Cancer Institute (NCI), National Institutes of Health - No specific Original Equipment Manufacturers (OEMs) or commercial vendors are named in this opportunity - Requested services: - Establish or maintain a Pharmacokinetics Resource Laboratory (PK Laboratory) - Organize biospecimen collections for ETCTN clinical trials - Conduct analyses of pharmacokinetic endpoints, drug-drug interactions, cytochrome P450 interactions, pharmacodynamics, and food effects for NCI Investigational New Drug (IND) agents - Provide technical services, scientific leadership, and biospecimen management cores - Unique requirements: - Applicants must have infrastructure and expertise for PK studies - Eligible applicants include nonprofits and higher education institutions - Funding instrument is a cooperative agreement - Estimated award value is $850,000 for one recipient - No specific products, part numbers, or OEM equipment are requested; the focus is on technical and scientific laboratory services - Place of performance and contracting office: National Cancer Institute

Description

The National Cancer Institute (NCI) plans to publish a Notice of Funding Opportunity (NOFO) to solicit applications from institutions to establish or maintain a Pharmacokinetics Resource Laboratory (PK Laboratory) supporting the Experimental Therapeutics Clinical Trials Network (ETCTN). The PK Laboratory will manage biospecimen collections and analyze pharmacokinetic endpoints, drug interactions, pharmacodynamics, and food effects in ETCTN studies of NCI Investigational New Drug agents. The goal is to advance clinical development of these agents by providing comprehensive pharmacokinetic data. Applications will require cores for technical services, scientific leadership, and biospecimen management. The NOFO is expected to be published in Summer 2025 with applications due in Fall 2025.

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