Simpler Grants.gov #PAR-28-010

NIH Funding Opportunity for Pragmatic Trials in Health Care Systems

The National Institutes of Health (NIH) is preparing to release a Notice of Funding Opportunity (NOFO) for large-scale pragmatic and implementation trials in health care systems. - Government Buyer: - National Institutes of Health (NIH), including the National Center for Complementary and Integrative Health (NCCIH) - Scope: - Funding supports research projects testing the effectiveness of interventions and strategies for delivering interventions in routine clinical care settings - Trials should be conducted in real-world health care environments - Applicants are encouraged to include multiple health system types and diverse care settings - Projects should assess adaptation across different systems and regions - Award Structure: - Milestone-driven cooperative agreement mechanism - Includes both a planning phase and a full trial execution phase - Eligibility: - Open to small businesses, educational institutions, tribal governments, nonprofits, federal agencies, and other organizations - No specific OEMs, vendors, products, or purchase quantities are identified, as this is a research grant opportunity - Unique Requirements: - Focus on pragmatic trials in routine care - Emphasis on diversity of health system types and adaptability across regions

Description

The National Institutes of Health intends to publish a Notice of Funding Opportunity (NOFO) for Pragmatic and Implementation Trials Conducted in Health Care Settings. This funding opportunity supports large-scale pragmatic trials testing intervention effectiveness in routine clinical care and implementation trials evaluating strategies for delivering interventions within health care settings. The trials aim to inform decision-makers about the comparative benefits, burdens, and risks of biomedical or behavioral interventions. Applicants are encouraged to select care settings where the target condition is commonly seen, include multiple health system types, and assess adaptation across systems and regions. The award uses a milestone-driven cooperative agreement mechanism supporting a planning phase and a full trial execution phase.

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