Opportunity

Simpler Grants.gov #PAR-25-323

NIH Stephen I. Katz Early Stage Investigator Research Project Grant (R01) Solicitation

Buyer

National Institutes of Health

Posted

August 25, 2025

Respond By

May 24, 2026

Identifier

PAR-25-323

NAICS

541715

The National Institutes of Health (NIH) is inviting applications for the Stephen I. Katz Early Stage Investigator Research Project Grant (R01), aimed at supporting innovative research by early stage investigators (ESIs) who are pursuing a new research direction without preliminary data. - Government Buyer: - National Institutes of Health (NIH) - Scope and Focus: - Supports basic science experimental studies involving human participants - Projects must represent a significant change in research direction for the investigator - No preliminary data may be included in the application - Research must align with the scientific missions of participating NIH Institutes and Centers (e.g., cancer, aging, mental health, environmental health) - Eligibility: - Open to a wide range of U.S.-based organizations, including higher education institutions, school districts, for-profit and nonprofit organizations, and tribal governments - Non-domestic entities and foreign components are not eligible - Application Requirements: - Must include a separate attachment describing the change in research direction - No specific products, services, OEMs, or vendors are requested - Unique Requirements: - Focus on early stage investigators without preliminary data - Emphasis on innovative, high-impact research directions - Place of Performance: - National Institutes of Health (NIH)

Description

The Stephen I. Katz Early Stage Investigator Research Project Grant supports an innovative project representing a change in research direction for an early stage investigator without preliminary data. The project must relate to the programmatic interests of participating NIH Institutes and Centers and involve basic science experimental studies with human participants. These studies prospectively assign human participants to conditions and assess biomedical or behavioral outcomes to understand fundamental phenomena without specific application towards processes or products. Applications must include a separate attachment describing the change in research direction and must not include preliminary data.

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