Simpler Grants.gov #PA-27-101

NIH SBIR Phase IIB Strategic Breakthrough Grant for Technology Commercialization

This opportunity is a planned grant from the National Institutes of Health (NIH) to support U.S. small businesses in advancing health-related technologies toward commercialization. - Government Buyer: - National Institutes of Health (NIH), including multiple Institutes and Centers (e.g., NCI, NEI, NHLBI, NIA, NIAAA, NIAID, NICHD, NIDDK, NIGMS, NIMH, NIMHD, NINDS, NCATS, ORIP, ORWH) - Products/Services Requested: - SBIR Phase IIB Strategic Breakthrough Grant Application - Grant funding for technology commercialization projects - For U.S. small businesses with prior NIH SBIR or STTR Phase II awards - Projects must require significant time, regulatory approval, or complex development - Applicants must provide at least 100% matching funds - Only one Phase IIB award per project is allowed - Supports renewal or resubmission applications - Encourages collaborative efforts - Unique/Notable Requirements: - Broad eligibility across health research areas (e.g., cancer, cardiovascular, diabetes, mental health, vision, lung diseases, minority health, aging, child health, blood diseases, sleep disorders, research infrastructure, translational sciences, women's health, allergy, infectious diseases, neuroscience, biomedical research) - Funding instrument is a grant, not a contract - Only U.S. small businesses with prior relevant NIH awards are eligible - Matching funds requirement is strictly enforced - No specific OEMs or commercial vendors are named, as this is a grant opportunity for small businesses developing their own technologies.

Description

The NIH plans to publish a Notice of Funding Opportunity inviting eligible U.S. small business concerns to submit SBIR Phase IIB Strategic Breakthrough grant applications. The award aims to advance technology toward commercialization, addressing the funding gap known as the "Valley of Death" by providing additional support for projects requiring significant time, regulatory approval, or complex development. Only U.S. small businesses that previously received an NIH SBIR or STTR Phase II award are eligible, and applicants must demonstrate at least 100% matching funds. Collaborative efforts are encouraged, and the funding instrument type is a grant.

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