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DARPA Protean Program: Research for Medical Countermeasures Restoring Protein Function Against Chemical Threats

DARPA's Biological Technologies Office is seeking proposals for the Protean program, focused on developing next-generation medical countermeasures (MCMs) that restore protein function to protect against chemical threat agents. - Government Buyer: - Defense Advanced Research Projects Agency (DARPA), Biological Technologies Office (BTO) - Products/Services Requested: - Research and development services to create innovative prophylactics and therapeutics that restore or protect protein function against chemical threats - Focus on three protein targets: Acetylcholinesterase, Mu Opioid Receptor, and ion channels - Approaches may include structural biology, computational modeling, and drug design - Solutions must provide protection at up to 10,000x lethal dose (LD50) of chemical agents - Unique or Notable Requirements: - Emphasis on broad-spectrum protection against current and future chemical threats - Mechanistic characterization and optimization pipelines for efficacy - Compliance with Controlled Unclassified Information (CUI) protection, export control laws, and DFARS/NIST cybersecurity standards - No specific OEMs or vendors named; open to all qualified sources - Period of Performance: - 33-month program divided into two phases: Phase 1 (18 months) for intervention point identification, Phase 2 (15 months) for countermeasure design and optimization - Place of Performance: - DARPA Biological Technologies Office, Arlington, VA

Description

This Research Announcement represents a solicitation for a research thrust, entitled Protean, that will focus on identifying novel ways to restore protein function to targets of chemical threat agents. The solicitation seeks innovative proposals for the design of medical countermeasures (MCMs) that provide complete protection against current and future chemical threats. The program aims to develop prophylactics and optionally therapeutics that protect protein function against chemical threat challenges at high lethal doses. Multiple awards may be made under this opportunity, and the types of instruments that may be awarded include Cooperative Agreements and Research Other Transactions Awards.

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