Opportunity
Simpler Grants.gov #PAR-27-011
NIH Funding for Single-Site Investigator-Initiated Clinical Trials (R61/R33)
Buyer
National Institutes of Health
Posted
March 18, 2026
Respond By
November 02, 2028
Identifier
PAR-27-011
NAICS
541715
The National Institutes of Health (NIH), through the Division of Cardiovascular Sciences, is offering funding for investigator-initiated single-site clinical trials: - Government Buyer: - National Institutes of Health (NIH), Division of Cardiovascular Sciences - National Heart, Lung, and Blood Institute (NHLBI) - Scope of Opportunity: - Funding supports single-site clinical trials in cardiovascular, lung, blood, and sleep disorders - Trials may include efficacy, comparative effectiveness, pragmatic, dissemination, and implementation science studies - Innovative trial designs (platform, adaptive, Bayesian) are encouraged - Requirements: - Applicants must submit a comprehensive scientific and operational plan - Project management, participant recruitment/retention, performance milestones, scientific conduct, and dissemination of results - Emphasis on community engagement and reducing health outcome disparities - Eligibility: - Open to government, nonprofit, educational, business, and certain foreign entities (with restrictions on foreign subawards/subcontracts) - No specific OEMs, vendors, or products are requested, as this is a grant for research activities, not a procurement of goods or equipment
Description
This Notice of Funding Opportunity (NOFO) supports applications to develop and conduct investigator-initiated single site clinical trials including efficacy, comparative effectiveness, pragmatic and/or dissemination and implementation science clinical trials. Trials using innovative designs such as platform trials, adaptive, and Bayesian designs are encouraged. The application should present the scientific rationale and a comprehensive scientific and operational plan, addressing project management, participant recruitment, performance milestones, scientific conduct, and dissemination of results. The NOFO aims to increase community engagement, close health outcome gaps in the US population, and improve health for all.