Opportunity

Simpler Grants.gov #RFA-RM-26-003

NIH Director’s Transformative Research Award Grant Opportunity for Innovative Biomedical Projects

Buyer

National Institutes of Health

Posted

January 06, 2026

Respond By

September 03, 2026

Identifier

RFA-RM-26-003

NAICS

541715, 541714, 541713

The National Institutes of Health (NIH) is inviting applications for the Director’s Transformative Research Award, aimed at supporting exceptionally innovative and high-impact biomedical research projects. - Government Buyer: - National Institutes of Health (NIH) - Program Details: - Part of the NIH Common Fund’s High-Risk, High-Reward Research (HRHR) Program - Supports bold, groundbreaking research with the potential to create new scientific paradigms, clinical approaches, or transformative technologies - No preliminary data required for application - Open to a wide range of applicants, including government entities, businesses, educational institutions, nonprofits, and certain federal agencies (excluding NIH Intramural Research Program) - Products/Services Requested: - Funding for biomedical research projects (no specific products, OEMs, or part numbers requested) - Unique Requirements: - Projects must demonstrate compelling potential for major impact in areas relevant to NIH - Emphasis on transformative, paradigm-shifting research - No OEMs, vendors, or specific products are mentioned, as this is a research grant opportunity rather than a procurement of goods or commercial services.

Description

The NIH Director’s Transformative Research Award supports individual scientists or groups proposing bold, groundbreaking, and innovative research with the potential to create new scientific paradigms, establish improved clinical approaches, or develop transformative technologies. Applications in any area within the biomedical sciences are welcome, and no preliminary data are required. Projects must demonstrate a compelling potential to produce a major impact in a broad area relevant to the NIH. This award is part of the High-Risk, High-Reward Research Program of the NIH Common Fund.

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