Simpler Grants.gov #RFA-TR-25-016

NIH Grant for Advanced 3-D Tissue Models for Drug Screening

This opportunity from the National Institutes of Health (NIH), through the National Center for Advancing Translational Sciences (NCATS), seeks applications for developing advanced 3-D tissue models for drug screening. - Government Buyer: - National Institutes of Health (NIH) - National Center for Advancing Translational Sciences (NCATS) - Products/Services Requested: - Research and development of non-animal, physiologically relevant 3-D tissue models - Models must be robust, reliable, and adaptable to high-throughput drug screening - Utilization of the NCATS 3-D Bioprinting laboratory's expertise and infrastructure is required - Unique/Notable Requirements: - Focus on non-animal models that closely mimic structural, biochemical, and mechanical tissue properties - Models must improve predictive accuracy for drug efficacy testing - Open to a wide range of U.S.-based government, nonprofit, business, and educational organizations - Foreign institutions and non-domestic components are not eligible - Funding Details: - Cooperative agreement with an estimated total funding of $1,600,000 - Two expected awards - No specific OEMs or commercial vendors are named, as this is a research grant opportunity

Description

The National Institutes of Health (NIH) intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for developing, validating, and demonstrating advanced 3-D tissue models for drug screening. These models aim to test the efficacy of various therapeutic modalities, including small molecules and biologics, to accelerate new therapeutic discoveries across diseases. The initiative focuses on creating non-animal 3-D drug screening models that mimic tissue properties for improved predictive accuracy and are adaptable to high throughput assays. Applicants must utilize the NCATS 3-D Bioprinting laboratory's expertise and infrastructure, ensuring models are physiologically relevant yet robust and suitable for drug screening.

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