Simpler Grants.gov #RFA-NS-26-034

NIH Notice: Functional Target Validation for Alzheimer's Disease-Related Dementias Research Grants

This notice from the National Institute of Neurological Disorders and Stroke (NINDS), part of the NIH, outlines a planned grant opportunity for research on functional target validation in Alzheimer’s Disease–Related Dementias (ADRD): - Government Buyer: - National Institutes of Health (NIH) - National Institute of Neurological Disorders and Stroke (NINDS) - OEMs and Vendors: - No specific OEMs or vendors are mentioned; this is a research grant opportunity - Products/Services Requested: - Research services for comprehensive functional validation of newly identified therapeutic targets for ADRD - Development of customized technologies, models, and protocols to modulate candidate targets and assess physiological consequences in disease models - No specific part numbers or product quantities are specified - Unique or Notable Requirements: - Milestone-based technical feasibility and proof-of-concept criteria - Cross-validation across multiple experimental modalities - Adherence to NIH rigor and reproducibility guidelines - Phased award mechanism (e.g., R61/R33) to support project progression - Notice is for planning purposes; applications are not yet being solicited

Description

The National Institute of Neurological Disorders and Stroke (NINDS) seeks to support research projects for comprehensive functional validation of newly identified therapeutic target candidates for Alzheimer’s Disease–Related Dementias (ADRD). The initiative aims to overcome barriers in developing effective treatments by ensuring rigorous target validation linked to disease mechanisms. It supports a phased award mechanism to develop technologies and models to modulate candidate targets and assess their physiological consequences in disease models. This notice is to allow potential applicants time to develop projects and collaborations; applications are not being solicited at this time.

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