Simpler Grants.gov #RFA-NS-26-031

NINDS Solicits Research on Exposomic Factors in ADRD Pathology and Resilience

The National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health, is seeking research projects focused on how neural exposome factors influence Alzheimer’s disease-related dementias (ADRD) pathology and resilience. - Government Buyer: - National Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health - OEMs and Vendors: - No specific OEMs or vendors are mentioned; this is a research grant opportunity - Products/Services Requested: - Research projects investigating the combined effects of exposome factors (e.g., environmental toxins, sleep, circadian rhythms, stress, real-world conditions) on neural mechanisms relevant to ADRD - Mechanistic pathways of interest include: - Microbiome–brain interactions - Neuroimmune signaling - Epigenetic modifications - Studies should address: - Lifespan and critical exposure periods - Health disparities - Mechanistic, translational, and human subjects research (excluding NIH-defined clinical trials) - Unique or Notable Requirements: - Emphasis on expertise in exposomics, environmental neuroscience, community engagement, ADRD mechanisms, and health disparities - Use of clinical data, human samples, and observational or interventional studies - NIH-defined clinical trials are not supported

Description

The National Institute of Neurological Disorders and Stroke (NINDS) seeks research projects investigating how specific neural exposome factors contribute mechanistically to Alzheimer’s disease-related dementias (ADRD) pathology and resilience. Research should focus on the synergistic action between multiple exposome factors and their composite effects on neural mechanisms relevant to ADRD, including pathways like microbiome–brain interactions, neuroimmune signaling, and epigenetic modifications. Studies covering the lifespan, critical exposure periods, and health disparities are encouraged, with suitable research types including mechanistic, translational, and human subjects research. NIH-defined clinical trials are not supported. This opportunity is a notice for potential applicants to develop collaborations and projects.

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