Opportunity
Simpler Grants.gov #PAR-25-449
NIH Solicitation for Mind and Body Interventions Research on Emotional Well-Being Mechanisms (R61/R33 Clinical Trial Required)
Buyer
National Institutes of Health
Posted
September 26, 2025
Respond By
June 07, 2028
Identifier
PAR-25-449
NAICS
541715
This opportunity from the National Institutes of Health (NIH), through the National Center for Complementary and Integrative Health (NCCIH), seeks research proposals on mind and body interventions for emotional well-being and whole person health. - Government Buyer: - National Institutes of Health (NIH) - National Center for Complementary and Integrative Health (NCCIH) - Scope of Solicitation: - Research grants for mechanistic clinical trials on mind and body interventions - Focus on interventions such as mindfulness meditation, yoga, acupuncture, massage, and other brain/body-based approaches - Two-phased award structure (R61/R33): - Initial feasibility phase (R61) - Full-scale trial phase (R33), contingent on milestone completion - Requires strong preliminary data, comparable to R01-level proposals - Eligibility: - Open to U.S.-based educational, nonprofit, governmental, and business entities - Excludes non-U.S. organizations and foreign components - Notable Requirements: - Emphasis on rigorous, mechanistic studies - Clinical trial required - No specific OEMs or vendors identified, as this is a research grant - Funding Opportunity Number: PAR-25-449
Description
The National Center for Complementary and Integrative Health (NCCIH) is soliciting applications for research on how mind and body interventions such as mindfulness meditation, yoga, acupuncture, and massage impact mechanisms of emotional well-being and their association with whole person health. The funding supports rigorous mechanistic clinical trials using a two-phased award mechanism (R61/R33), with the initial phase establishing feasibility and the second phase completing full-scale trials contingent on milestone completion. Applications must provide strong preliminary data comparable to R01 proposals. The research aims to address NIH priorities to improve health and well-being of the American people.