Opportunity

Simpler Grants.gov #RFA-CA-25-031

NCI Metastasis Research Network U54 Centers – Multidisciplinary Cancer Metastasis Research Funding

Buyer

National Institutes of Health

Posted

November 19, 2025

Respond By

May 15, 2026

Identifier

RFA-CA-25-031

NAICS

541711

The National Cancer Institute (NCI) is inviting applications for the Metastasis Research Network (MetNet) U54 Centers to advance multidisciplinary research on cancer metastasis. - Government Buyer: - National Institutes of Health (NIH), National Cancer Institute (NCI) - Products/Services Requested: - Establishment of U54 Specialized Centers serving as research hubs - Execution of 2-3 integrative, systems-level basic research projects per center - Focus areas include early dissemination, microenvironment crosstalk, dormancy, and therapy response mechanisms in cancer metastasis - All cancer types, including rare and pediatric, are eligible for study - Unique or Notable Requirements: - Applicants must propose an overarching scientific theme - Broad eligibility: higher education institutions, nonprofits, government entities, tribal organizations, and for-profit businesses - No specific OEMs, vendors, or commercial products are required; this is a research grant opportunity - Funding Details: - Total estimated funding: $6,800,000 - Minimum award: $1,700,000 - Place of Performance: - National Institutes of Health (NIH)

Description

The National Cancer Institute (NCI) is soliciting applications for research to develop a comprehensive understanding of cancer metastasis. The funding supports U54 Specialized Centers that will serve as hubs of the Metastasis Research Network (MetNet), each proposing an overarching scientific theme pursued through 2-3 multidisciplinary basic research projects using integrative system-level approaches. Research themes should include interactions such as early dissemination, microenvironment crosstalk, dormancy, or therapy response mechanisms, and studies on all cancer types, including rare and pediatric cancers, are welcome. The goal is to advance understanding of metastasis as a whole-body, systems-level problem.

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