Opportunity
Simpler Grants.gov #RFA-OD-25-020
NIH INCLUDE Project: Transformative Research Awards for Down syndrome (R01 Clinical Trial Not Allowed)
Buyer
National Institutes of Health
Posted
September 25, 2025
Respond By
February 19, 2026
Identifier
RFA-OD-25-020
NAICS
541715
The National Institutes of Health (NIH) is inviting applications for the INCLUDE Project: Transformative Research Awards for Down syndrome. - Government Buyer: - National Institutes of Health (NIH) - Products/Services Requested: - Transformative, innovative research projects focused on Down syndrome and its co-occurring conditions - No specific products, part numbers, or quantities are specified, as this is a research grant opportunity - Unique or Notable Requirements: - Projects must propose groundbreaking research with the potential to create new scientific paradigms, clinical approaches, or transformative technologies - No preliminary data required for application - Open to a wide range of applicants, including nonprofits, educational institutions, government entities, businesses, and foreign organizations - Emphasis on major impact and originality in Down syndrome research - OEMs and Vendors: - No OEMs or vendors are specified, as this is a grant for research rather than a procurement of goods or services - Funding Details: - Total program funding: $3,000,000 - Individual awards: $250,000 to $500,000 - Place of Performance: - National Institutes of Health (NIH)
Description
The NIH INCLUDE Project aims to improve health and quality-of-life for individuals with Down syndrome by soliciting Transformative Research Award applications. These awards support groundbreaking, innovative, and original research with the potential to create new scientific paradigms or develop transformative technologies related to Down syndrome. Applications are welcome on all topics relevant to Down syndrome or its co-occurring conditions, and no preliminary data are required. Projects must demonstrate a compelling potential to produce a major impact in Down syndrome research.