Simpler Grants.gov #PAR-26-049

NIMH Presolicitation: Research on Pediatric CNS Pharmacodynamic Measures for Psychiatric Indications

The National Institute of Mental Health (NIMH), part of the National Institutes of Health, is announcing a forthcoming research funding opportunity focused on pediatric psychiatric drug development. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Mental Health (NIMH) - Purpose: - Research to develop and refine central nervous system (CNS) pharmacodynamic measures for use in adolescent psychiatric clinical trials - Emphasis on tools and models such as EEG, fMRI, digital health measures, and cognitive assessments - Scope: - Studies should link dosing strategies, pharmacokinetics, and pharmacodynamics to improve safety and effectiveness in pediatric trials - Validation and standardization of CNS measures for psychiatric indications in children and adolescents with serious mental illnesses - OEMs and Vendors: - No specific OEMs or vendors are named, as this is a research grant opportunity - Products/Services Requested: - No commercial products or part numbers specified; focus is on research services and tool development - Unique Requirements: - Encourages collaboration and project planning prior to application - No applications are being accepted yet; this is a presolicitation notice

Description

The National Institute of Mental Health (NIMH) seeks research to determine optimal dosing strategies for new psychiatric medications in children and adolescents with serious mental illnesses. The focus is on developing and refining central nervous system (CNS) tools and models, such as EEG, fMRI, digital health measures, or cognitive assessments, to show medication effects on the brain in young people. Studies should explore how dosing impacts drug exposure (pharmacokinetics) and CNS functional effects (pharmacodynamics) to improve pediatric clinical trial safety and effectiveness. Applications are not currently being solicited; this notice allows potential applicants time to develop collaborations and projects.

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