Simpler Grants.gov #RFA-NS-25-031

NIH HEAL Initiative: Funding for Multisite Pain Management Clinical Trials

This opportunity is a planned funding release from the National Institutes of Health (NIH) for large, multisite clinical trials focused on pain management effectiveness as part of the HEAL Initiative. - Government Buyer: - National Institutes of Health (NIH) - National Institute of Neurological Disorders and Stroke (NINDS) - National Center for Advancing Translational Sciences (NCATS) - National Institute on Aging (NIA) - National Institute of Dental and Craniofacial Research (NIDCR) - National Center for Complementary and Integrative Health (NCCIH) - National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) - Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) - Products/Services Requested: - Large-scale, multisite clinical trials evaluating interventions or management strategies for pain - Focus on reducing opioid use, improving functional outcomes, and reducing pain in acute and chronic conditions - Unique/Notable Requirements: - No specific products, OEMs, or vendors are named - Funding instrument is a cooperative agreement (UG3/UH3 activity code) - Broad eligibility: nonprofits, businesses, government, educational, and foreign organizations - Applications are not yet being solicited; this is a forecasted opportunity - OEMs: None specified; this is a research funding opportunity, not a product procurement

Description

The National Institute of Neurological Disorders and Stroke (NINDS), along with several other NIH institutes, intends to publish a Notice of Funding Opportunity (NOFO) to solicit applications for large-scale, multisite clinical trials. These trials aim to inform clinicians about the efficacy or effectiveness of interventions that reduce opioid use, improve functional outcomes, and reduce pain across acute to chronic pain conditions. The NOFO will continue the HEAL Initiative Pain Management Effectiveness Research Network and seeks to expand evidence-based therapeutics for multiple pain conditions. Applications are not currently being solicited; this notice allows potential applicants time to develop collaborations and projects.

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